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Database (2009) Vol. 2009:bap008; doi:10.1093/database/bap008 published on August 7, 2009
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© 2009 The Author(s).
This is Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

miRò: a miRNA knowledge base

A. Laganà1,2,*, S. Forte1,2, A. Giudice2, M. R. Arena2, P. L. Puglisi2, R. Giugno2, A. Pulvirenti2, D. Shasha3 and A. Ferro1,2

1Department of Biomedical Sciences, University of Catania, Italy, 95124, 2Department of Mathematics and Computer Sciences, University of Catania, Catania, Italy, 95125 and 3Courant Institute of Mathematical Sciences, New York University, New York, USA, 10012-1185

*Corresponding author: Tel: +39 0957383082; Fax: +39 095330094; E-mail: lagana{at}dmi.unict.it Correspondence may also be addressed to A. Ferro. Tel: +39 0957383071; Fax: +39 0957337032; Email: ferro{at}dmi.unict.it


  Abstract

miRò is a web-based knowledge base that provides users with miRNA–phenotype associations in humans. It integrates data from various online sources, such as databases of miRNAs, ontologies, diseases and targets, into a unified database equipped with an intuitive and flexible query interface and data mining facilities. The main goal of miRò is the establishment of a knowledge base which allows non-trivial analysis through sophisticated mining techniques and the introduction of a new layer of associations between genes and phenotypes inferred based on miRNAs annotations. Furthermore, a specificity function applied to validated data highlights the most significant associations. The miRò web site is available at: http://ferrolab.dmi.unict.it/miro.

Database URL: http://ferrolab.dmi.unict.it/miro

Received January 30, 2009; Revised June 18, 2009; Accepted June 23, 2009

The authors wish it to be known that, in their opinion, the sixth and seventh authors should be regarded as joint authors.


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