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Database (2009) Vol. 2009:bap006; doi:10.1093/database/bap006 published on June 2, 2009
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© 2009 The Author(s).
This is Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

DBH2H: vertebrate head-to-head gene pairs annotated at genomic and post-genomic levels

Hui Yu1,2, Fu-Dong Yu2, Guo-Qing Zhang1,2, Xiang Shen2, Yun-Qin Chen2,3, Yuan-Yuan Li1,2,* and Yi-Xue Li1,2,*

1Bioinformatics Center, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 2Shanghai Center for Bioinformation Technology, Shanghai 200235 and 3College of Life Science and Technology, Tongji University, Shanghai 200092, China

*Corresponding author: Tel: +86 21 54065018; Fax: +86 21 54065058; Email: yyli{at}scbit.org Correspondence may also addressed to Yi-Xue Li. Tel: +86 21 54065001; Fax: +86 21 54920143; Email: yxli{at}sibs.ac.cn


  Abstract

DBH2H collects head-to-head (h2h) gene pairs identified from human, mouse, rat, chicken and fugu genomes, and distinguishes the ortholog mapping relationship among them. The gene pairs in DBH2H are annotated with sequential features including single nucleotide polymorphisms, CpG islands and transcription factor binding sites, as well as functional terms and genetic disorders. In addition, the expression correlation information based on 117 microarray datasets is included. By providing user-friendly access to these data, DBH2H represents a valuable resource for further analyses of this important gene arrangement in terms of transcriptional regulation mechanisms, evolutionary conservation, disease relevance, etc.

Database URL: http://lifecenter.sgst.cn/h2h/

Received November 23, 2008; Revised March 25, 2009; Accepted April 24, 2009


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